A small trial found that giving twelve postmenopausal women a
daily boron supplement (3mg) for around seven weeks had reduced
(i) total plasma concentration of calcium and (ii) urinary excretions
of calcium and magnesium, while boosting levels of elevated the
serum concentrations of the sex hormones 17 beta-estradiol and
This suggested that boron might both protect against bone loss
and be a natural and safer alternative to HRT.
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The second trial involved five men over the age of 45, four postmenopausal
women, and five postmenopausal women on HRT on a low-magnesium
diet marginally adequate in copper. In this case the three milligram
boron supplement increased levels of erythrocyte superoxide dismutase,
serum enzymatic ceruloplasmin and plasma copper.
The third trial was the same as the second, except that this
time it was adequate in both magnesium and copper. The increases
in plasma copper and serum 17 beta-estradiol concentrations achieved
by HRT were reinforced by boron supplementation.